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SEMFLEX－II^®

Undenatured Collagen Type II Manufacturer

85-90% of the collagen in articular cartilage is type II collagen, and a patented manufacturing process ensures that the unique spatial structure of type II collagen is maintained.

Undenatured type II collagen is found in a triple helical structure consisting of three interconnected (cross-linked) collagen fibers.

When taken orally, specific components of the intact helical structure are recognized by the immune system in the gut. Repeated ingestion can lead to oral tolerance of type II collagen.

SEMFLEX-II® undenatured type II collagen is produced by low-temperature extraction of chicken breast cartilage as raw material using self-developed patented technology. The product retains the collagen triple helix structure intact and is insoluble in water and ethanol.

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Application:

Osteoporosis: It can effectively increase bone density, improve bone strength and flexibility, with the biochemical properties of adsorption and adhesion to calcium ions deposited in the bone, promote the generation and growth of bone, metabolic repair and reconstruction, efficiently and safely solve the loss of bone and prevent and control osteoporosis.

Osteoarthritis: Promote the repair and regeneration of cartilage and ligament tissues, lubricate joints, eliminate bone spurs, absorb edema, effectively and safely prevent and treat all kinds of arthritis (including lumbar disc herniation).

Necrosis of femoral head:It can form new blood vessel buds and grow new blood suits in cup dead tissues, rebuild and form nutrient transportation channels, improve the blood situation of the ring dead damage parts and surrounding tissues, gradually form and restore the blood supply of the cup dead tissues, and through bone resorption, bone reconstruction, complete or the removal of the bone wastes of the cup dead tissues and the growth of the new bone tissues.

Product Features:

● Patented process；

● Low-temperature extraction；

● Complete preservation of collagen triple helix structure.

Authorized Patents:

①ZL 201811175742.2

②ZL 202110308583.4

Publications:

[1] Influences of Oral Undenatured Collagen Type II on Knee Joint Range of Motion in Patients with Knee Osteoarthritis——Journal of Medical Biomechanics

[2] Research Progress of Undenatured Type II Collagen on Osteoarthritis——Science and Technology of Food Industry

[3] The Effects of Undenatured Type II Collagen on Inflammatory Mediators and Oxidative Stress in an Osteoarthritis Rat Model——2020 International Conference on Energy, Natural Resources and Electric Power (ENREP 2020)

Specification

Product Name		Undenatured Collagen Type II
Raw Material	Chicken Sternal Cartilage		Test Method
Appearance	Color	Cream or Light Yellow	Q/ASMN0001S-2020
	Smell	CollagenCharacteristic Smell
	Form	Fine Powder
Physical Chemical Properties	Density	0.2-0.7	QC standard
	Percent Pass 60 mesh	≥ 98.0	QC standard
	Water g/100g	≤10.0	GB 5009.3
	Protein(dry basis) g/100g	≥ 45.0	GB 5009.5
	Undenatured Collagen II g/100g	≥ 15.0	HPLC
	Potassium g/100g	≤20.0	GB 5009.91
Heavy Metals	As mg/kg	≤ 0.5	GB 5009. 11
	Pb mg/kg	≤ 0.5	GB 5009. 12
	Cd mg/kg	≤ 0.09	GB 5009.15
	Hg mg/kg	≤ 0.09	GB 5009.17
Microbiological Standard	Total Plate Count CFU/g	≤1000	GB 4789.2
	Coliforms CFU/g	＜10	GB 4789.3
	Yeast/Mold CFU/g	≤50	GB 4789.15
	Salmonella	Absent	GB 4789.4
	Staphylococcus Aureus	Absent	GB 4789.10
Packing	10 kg/bag,20kg/box; Inner: PE+foil bag;Outer: box
Storage	Store in a cool dry place away from heat and direct sunlight.
Shelf Life	36 months

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